Structural determinants of human ζ-globin mRNA stability
نویسندگان
چکیده
منابع مشابه
Structural determinants of human ζ-globin mRNA stability
BACKGROUND The normal accumulation of adult α and β globins in definitive erythrocytes is critically dependent upon processes that ensure that the cognate mRNAs are maintained at high levels in transcriptionally silent, but translationally active progenitor cells. The impact of these post-transcriptional regulatory events on the expression of embryonic ζ globin is not known, as its encoding mRN...
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Messenger RNA (mRNA) stability is a critical determinant that affects gene expression. Many pathways have evolved to modulate mRNA stability in response to developmental, physiological and/or environmental stimuli. Eukaryotic mRNAs have a considerable range of half-lives, from as short as a few minutes to as long as several days. Human globin mRNAs constitute an example of highly stable mRNAs. ...
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ژورنال
عنوان ژورنال: Journal of Hematology & Oncology
سال: 2014
ISSN: 1756-8722
DOI: 10.1186/1756-8722-7-35